Postdoctoral Fellow, Gene Regulation - de Boer Lab
The University of British Columbia (UBC)
Vancouver, Canada
3h ago
source : Euraxess

A postdoctoral research fellow position to study gene regulation is available in the in the School of Biomedical Engineering (SBME) at the University of British Columbia (UBC) in Vancouver, BC, Canada.

The goal of this project is to learn how regulatory DNA sequences encode for gene expression. We develop new computational and experimental tools to learn how regulatory DNA functions, and how this function changes with genetic variation.

As a mixed computational / experimental group, we offer many opportunities for unique training.

The Faculties of Medicine and Applied Science have partnered to create the SBME, a new flagship entity at UBC, and a top strategic priority for the University and both Faculties.

The SBME is a nucleus for education and training, research, and innovation in biomedical engineering, creating new knowledge, new academic and training programs, and fostering translation and innovation.

UBC SBME students will distinguish themselves by a deep education in biology, deconstructed using engineering science and design, and applied to the solution of real-world biomedical challenges.

Our SBME faculty conduct research that advances our fundamental understanding of human biology, and yields technologies and therapies that advance our health and wellbeing.

Responsibilities

An end goal of our research is to understand how DNA sequences encode gene regulatory programs. For instance, distal enhancers regulate the expression of nearby genes by virtue of the sequence of their DNA, which is read out by proteins termed transcription factors.

Much of our experimental work aims to create ideal datasets for learning how the cell goes from DNA sequence to gene regulation.

We use Machine Learning to learn this relationship, and the underlying biological mechanisms. The responsibilities of this position, to be determne by the Supervisor, are flexible and will depend on the skills and researchinterests of the successful applicant.

In particular, responsibilities need not include both computational and experimental components.

Specific tasks may include :

  • Developing high-throughput reporter assays (enhancers, promoters, RNA);
  • Developing genetic / epigenetic CRISPR / Cas9 screens;
  • Designing and implementing new research projects;
  • Creating computational models Neural Networks) relating nucleic acid sequence to gene regulatory programs;
  • Bioinformatic algorithm design;
  • Using computer models and other software to make inferences on the nature of phenotype-linked human genetic variation;
  • Experimental validation of predictions;
  • Writing fellowship applications;
  • Assisting with grant applications and drafting publications; &
  • Helping to train and mentor lab personnel.
  • Qualifications

  • Strong candidates in either computational or experimental biology (or both) will be considered.
  • Competitive candidates must hold a PhD, MD, or equivalent degree by the time of their appointment. Preference will be given to candidates that recently (
  • Candidates should have a strong research background, as demonstrated by past publications, accomplishments, and references.
  • The successful candidate will be a passionate, self-driven, independent thinker with excellent organizational, oral and written communication, excellent interpersonal skills, and a strong work ethic.
  • Important experimental skills : next-generation sequencing, genome editing, high-throughput reporter assays, transcriptomic, ChIP-seq, library cloning, cell culture, lentivirus, transfection and ESC culture.
  • Important computational skills : python, Tensorflow, deep learning, statistics, linux, R, algorithm development, machine learning / AI, cloud computing.
  • While this position is grant-funded, the successful applicant will be expected to apply for external fellowship funding.
  • Start date, stipend, and location

    The start date is immediate but flexible; funding has already been received and salary will be commensurate with qualifications and experience.

    The position is full-time for one year with the possibility of extension. The funding package consists of a stipend and benefits.

    How to Apply

    Candidates should provide a CV, contact information of 3 references, and a cover letter describing past achievements and future research interests.

    Candidates with computational experience should also include a sample of code they have written a link to their GitHub page).

    In addition to applying through the UBC Faculty Careers website, applications can also be emailed to Dr. Carl de Boer (

    This posting is for the campus.

    Please refer to reference number EU-54339 during correspondence about this position.

    Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.

    We encourage applications from members of groups that have been marginalized on any grounds enumerated under the Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and / or status as a First Nation, Metis, Inuit, or Indigenous person.

    About UBC

    The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world.

    Since 1915, UBC's entrepreneurial spirit has embraced innovation and challenged the status quo. UBC encourages its students, staff and faculty to challenge convention, lead discovery and explore new ways of learning.

    At UBC, bold thinking is given a place to develop into ideas that can change the world.

    About UBC's Faculty of Applied Science

    The Faculty of Applied Science includes all UBC Engineering activities at both the UBC Vancouver and UBC Okanagan, as well as the Schools of Architecture and Landscape Architecture, Community and Regional Planning and Nursing.

    The Faculty was one of UBC's three founding faculties, admitting some of the University's first students in engineering in 1915.

    The Faculty includes over 300 full-time faculty members and more than 8,600 students.

    The Faculty of Applied Science comprises a unique constellation of disciplines and is committed to creating lasting change by discovering and applying knowledge.

    Our core purpose is to discover, design, and innovate, provide unwavering top-tier education, and champion a community of responsible professionals devoted to serving a thriving, sustainable and healthy society.

    Our work and the professional disciplines we represent span the entire human-centred built environment. We represent innovation at all scales from nanoscale electronic devices that power communications to the design of entire cities.

    Offer Requirements

  • REQUIRED LANGUAGES ENGLISH : Excellent
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