Caprion is seeking a highly-motivated and enthusiastic Scientist for its Mass Spectrometry Proteomics team. This individual will play a key role in performing studies involving peptide profiling by LC-MS, peptide sequencing using tandem MS, SRM method development, and targeted peptide SRM data analysis and interpretation.
In addition, the Scientist may also be involved in sample preparation of biological fluids and tissue study samples involving a variety of techniques such as immuno-depletion, digestion and analysis by SCX / HPRP Chromatography following Standard Operating Procedures (SOP), Good Laboratory Practices (GLP) and Good Documentation Practices.
Perform studies involving peptide profiling by mass spectrometry;
General MS maintenance and troubleshooting;
Data analysis, interpretation and reporting of scientific results;
Work in close collaboration with a cross-functional team;
Participate in troubleshooting, investigations and CAPA;
Maintain study-related documentation according to GLP and regulatory guidance;
Monitor performance of equipment and record activities in equipment logbooks;
Monitor MS analysis on evenings and weekends, as needed;
Perform general laboratory duties;
Perform immuno-depletion procedures including sample clean up (ex. depletion, digestion, desalting, fractionation,) on large number of biological samples.
Main requirements and skills
Minimum of B.Sc. Chemistry, Biochemistry or related field;
Minimum of 3 years of experience in operation and maintenance of mass spectrometers;
Sample preparation and mass spectrometry knowledge;
Data analysis and interpretation skills;
Knowledge and understanding of GLP regulations;
Good record keeping, attention to detail and commitment to achieve good quality work;
Good communication skills;
Capacity to prioritize and organize workload and meet deadlines in a fast-paced, changing environment;
Ability to work in a team.
Must accept to perform duties and supervise activities in BSL2 environment;
Responsible for following Health and Safety Guidelines.
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