Postdoctoral Fellow
University Health Network
Toronto, Ontario, Canada
8d ago

Status : Temporary Full-Time (1 year)

POSITION :

University Health Network (UHN) is looking for an experienced professional to fill the key role of a n our Research Department.

Transforming lives and communities through excellence in care, discovery and learning.

The University Health Network, where above all else the needs of patients come first , encompasses Toronto Rehabilitation Institute, Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre and the Michener Institute of Education at UHN .

The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education.

With a long tradition of groundbreaking firsts and a purpose of Transforming lives and communities through excellence in care, discovery and learning , the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers.

UHN is a caring, creative place where amazing people are amazing the world.

University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network.

The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care.

Research across UHN's five research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. .

A POSTDOCTORAL position is available in the laboratory of Dr. Hakem at the Princess Margaret Cancer Centre / University Health Network, Toronto, Canada.

We seek applicants who are highly self-motivated and career-oriented .

Our research program focuses on understanding cancer mechanisms with the aim to identify novel therapeutic strategies for cancer patients.

The lab has excellent track records studying in vivo mechanisms and signaling pathways important for cancer, including DNA damage repair and NOTCH signaling.

These studies include in vivo functions of BRCA1, P53, MUS81, RNF8, RNF168 and CHK2 ( J Clin Invest . 128 : 4525-4542 : Nature Communicatio ns , DOI : 10.

1038 / ncomms12638; PNAS 110 : 20982-7; Science , 304 : 1822-1826; JEM . 207 : 983-97; Genes & Dev , 18 : 1144-1153; Nature Immunol ., 1 : 77-82).

Our studies are based on genetic, proteomic, transcriptomic, bioinformatics and molecular analyses in human cancer cell lines and mouse models, as well as data from cancer patients.

Several genome-wide CRISPR Cas9 screening are ongoing.

Candidate requirements :

  • PhD or MD / PhD degree obtained within the past 3 years
  • Demonstrated expertise in cell signaling and molecular biology
  • Experience withgenome-wide CRISPR-Cas9 screening is desirable
  • Highly self-motivated and creative individual with strong publication records (First author publications)
  • Excellent writing and communication skills
  • Ability to work effectively both independently and as a member of a team is a prerequisite.
  • Interested applicants should submit their C.V., names of three referees and a statement of research interest to Dr. Hakem ().

    Interested applicants should submit their C.V., names of three referees and a statement of research interest online.

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