Director, Histology and Histochemistry Group
4D Molecular Therapeutics
Emeryville, Emeryville, CA, Canada
11h ago

4D Molecular Therapeutics, located in Emeryville, CA is a global leader in gene therapy product research & development using scientific innovation to unlock the full potential of gene therapy for patients with genetic diseases.

At 4D Molecular Therapeutics, our goal is to design and develop transformative gene therapy products using our proprietary adeno-

associated virus variants platform to treat serious unmet medical conditions.

In order to streamline data generation, 4DMT is looking to hire an immunohistochemistry (IHC) expert to provide analysis of data, generate new protocols, manage in-

house work, identify work to be outsourced and monitor such work. This role will be an independent function that reports to the Chief Medical Officer / Head of Translational Medicine.

This function will be involved with multiple programs, in research to late stage preclinical programs. The data generated will inform doses for IND-

enabling studies and require high level of organization and ability to write reports that will be part of IND packages.


  • Propose and manage internal and outsourced projects with costs, timing, and quality rationale
  • Develop and direct IHC protocols including tissue fixation, trimming, embedding, sectioning, staining, and analysis
  • IHC assay development / validation and management of assay transfer to CRO for implementation in preclinical and clinical trials
  • Direct associate or CRO on H&E staining, immunofluorescence, or colorimetric staining
  • Develop in house or outsourced imaging (including high-throughput imaging)
  • Develop in house or outsourced image quantitative and / or semi-quantitative analyses
  • Identify outsourced resources for histopathology assessments of a multitude of tissue types
  • Review data and generate presentations for executive committee
  • Work with PM to develop timelines and to understand corporate goals to prioritize data generation
  • Scientific writing in support of non-clinical IHC IND data package

  • A BS or MS in a biological science
  • 7-10+ years of industry and / or academic experience performing and managing histology activities
  • Strong IHC experience including development of protocols
  • Ability to lead a highly focused scientific team to meet timelines and deliverables
  • Ability to work in and prioritize projects across a matrixed, cross-functional organization
  • Ability to implement new techniques in house or with a CRO
  • Must have experience working with CROs and to be able to communicate clearly protocol requirements
  • Confident and respectful when interacting with all levels of management
  • Strong interpersonal skills and professional demeanor
  • Travel Time : 10%
  • Apply
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