The Radiobiology and Health Branch at the Canadian Nuclear Laboratories (CNL) invites applications for a postdoctoral position in immune checkpoint therapy.
The position is intended for 2 years with a possibility of a 1-year extension. The position holder will conduct research on combining radiation and immune checkpoint therapy to treat cancer in animal models, and using gene editing screening method to identify sensitizing and resistance genes of treatment.
CNL, Canada's premier nuclear science and technology organization, is located next to the Algonquin Provincial Park. The incumbent will be expected to function efficiently and cooperatively with a team of scientists, technicians, and students.
The candidate will undertake all research activities pertaining to the project including but not limited to :
Assisting in preparation of research proposals,
Designing and performing experiments.
Maintaining appropriate experimental records and documentation
Developing, adapting, and implementing new research techniques and protocols.
Analyzing, interpreting, summarizing and compiling data.
Participating in publications and presentations as co-author.
Performing routine and complex laboratory procedures throughout the training period.
Operating and maintaining equipment and instruments.
Participating in laboratory meetings, journal clubs, branch / company scientific seminars, and conferences.
Providing technical guidance, on-the-job training, and leadership for technical staff and students.
The candidate must :
be legally eligible to work in Canada;
have completed their Ph.D., defended and have their thesis approved;
have completed their Ph.D. within 24 months of their appointment to CNL as a PDF, or
Is in a program that will lead to the acquisition of their Ph.D. within six (6) months of applying to the Program;
meet CNL’s Personnel Security Screening requirements.
It is preferred, but not necessary that the candidates Ph.D. was obtained from a Canadian university;
have two (2) publications representative of their research; and
have two (2) work-pertinent references
A Ph.D. degree in a relevant Biological / Biochemical discipline from a university of recognized standing completed within the last 24 months or within the next 6 months.
Experience with Crispr-Cas9 screening
Practical skills / experience working with mice, mouse cancer models, histology and histopathology, as wells as with conventional techniques involving RNA / DNA / protein work, qPCR, western blotting and fluorescence microscopy
Possess knowledge in one of the following areas : cell signalling, tumorigenesis, immune function as they pertain to questions in Tumor / Cancer Biology and as demonstrated by peer-reviewed publications and conference presentations
Demonstrated the ability to publish his / her research results as a lead author in the peer-reviewed scientific literature
Practical skills in statistical analyses and graphing / presentation of data
Completed Radiation Protection training or be willing to complete such training locally to be able to work with radiation sources and radioactive biological samples in Class C facility is must.
Effective verbal and written English communication skills to present results of research to both scientific and lay audience
The following will be considered as valuable assets :
Previous post-doctoral experience in a field relevant to immune checkpoint therapy
Experience and practical skills with the therapeutic mouse model
Experience with 3D cell culture / spheroid
Substantial knowledge in the areas of Radiation Biology, Radiation Oncology
Experience and familiarity with pathogen-free experimental animal facilities and associated standard operating procedures and requirements
This competition will remain posted until the position has been filled.