Senior Scientist - Mass Spectrometry
Montreal, QC, CA
4d ago
source : PostJobFree

Caprion Biosciences Inc. is a leading clinical research organization (CRO) laboratory in immune monitoring, protein characterization and tissue pathology solutions for immunotherapy and drug development.

We are located in Montreal, California, Chicago, Belgium, UK, Australia and soon in China. Employees at Caprion are true scientific partners working together to enhance people’s health and quality of life.

SummaryThis individual will work independently but closely with proteomics and bioinformatics scientists in a results-driven, collaborative environment.

He / she will be responsible for the choice of experimental methodology, carrying out the analyses and providing interpretations and conclusions from the results in a report for each project in a timely fashion.

The successful candidate will also advise the scientific team on general biomarker discovery questions, platform design, study design, and data analysis.

The Senior Scientist is expected to propose and implement new sample analysis procedures and / or improve existing ones.

The focus will be on conducting label-free differential quantification and identification of protein biomarkers using the Thermo QExactive as well as conducting MRM-based assays for marker verification and validation, using the Ab Sciex QTRAP systems.

Main ResponsibilitiesPerform sample preparation for a variety of biological materials.Perform mass spectrometry analysis and interpret results to ensure validity of conclusions.

Hands-on experience in operating a variety of electrospray-based LC / MS systems with a high comfort level.Responsible for method development both discovery and quantitative method.

Ability to also perform method development and validation of PK assay of biomarker(s) and drug products such as biologics / biosimilarsPerform in-depth data analysis and interpretation for each experimentProvide clear presentation and summary of analysis results and biological interpretation.

Design and execute experimental testingDesign and execute troubleshooting experimentsPropose and implement novel approaches to sample processing and mass spectrometry analysis.

Train Research Associate to perform new sample preparation or analytical techniques.Provide scientific recommendations to improve the quality of results and the platform.

Monitor data quality and take responsibility for project execution in the laboratory.Must be capable of working in a GLP environmentMain RequirementsM.

  • Sc. or Ph.D in life sciences, chemistry or biochemistry (or equivalent).;A minimum of 2 years of experience in method development in mass spectrometry;
  • Experience in conducting label-free differential quantification and identification of protein biomarkers;Experience in conducting MRM-based assays;
  • Solid understanding of mass spectrometry, molecular biology, protein chemistry;Prioritize, organize workload and meet deadlines in a fast-paced, changing environment.

  • Capable of supervision for specific projects will be an asset.The candidate must have excellent oral and written communications skills and be able to prepare project reports and make internal and client presentations;
  • Excellent interpersonal skills and ability to work collaboratively as part of a fast paced research team;Experience working in industry is a big plus;
  • May require working in BSL2 environment.

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