Postdoctral position
Toronto, Canada
24d ago

A POSTDOCTORAL position is available in the laboratory of Dr. R Hakem at the Princess Margaret Cancer Centre / University of Toronto / University Health network, Toronto, Canada.

The Princess Margaret Cancer Centre is one of the top five Cancer Research Centres in the world.

The Hakem lab’s research program focuses on understanding mechanisms of cancer initiation and progression and identification of novel therapeutic strategies for cancer patients.

The lab has a track record characterizing in vivo functions of tumor suppressors including BRCA1 ( Nature Immunol ., 1 : 77-

82; Genes & Dev , 18 : 1144-1153), MUS81 ( Science , 304 : 1822-1826), CASPASE 8 ( B lood . 119, p3495), RNF8 ( JEM . 207 : 983-

97) and RNF168 ( PNAS 110(52) : 20982-7; Nature Communication . DOI : 10.1038 / ncomms12638).

Biochemistry, proteomics, Chip-Seq, RNA-Seq, ATAC-Seq, genome-wide CRISPR Cas9 screening, mouse models and human samples are used for our studies.

Candidate requirements :

  • PhD or MD / PhD degree obtained within the past 3 years
  • Demonstrated expertise in cell signaling and molecular biology
  • Experience with CRISPR-Cas system is desirable
  • Highly self-motivated and creative individuals with strong publication records (First author publications)
  • Excellent writing and communication skills
  • The ability to work effectively both independently and as a member of a team is a prerequisite.
  • Interested applicants should submit their C.V., names of three referees and a statement of research interest to Dr. Hakem (rhakem

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